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Showing posts from April, 2019

The Autonomic Nervous System (ANS), Heart Rate Variability (HRV), Performance Anxiety, Propranolol, Vagus Nerve Stimulation and Autism

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Performance anxiety symptoms may include: ·        Racing pulse and rapid breathing. ·        Dry mouth and tight throat. ·        Trembling hands, lips, and voice. ·        Sweaty and cold hands. ·        Nausea  ·        Vision changes. Today’s post started out to be all about Propranolol, a very old and widely prescribed drug that lowers your blood pressure, but does other interesting things as well. It is used to treat several psychiatric disorders and has been widely trialled in autism. As I started researching I decided to broaden the post to bring in Heart Rate Variability (HRV), which one reader of this blog suggested as a useful measure of the effect of supplements.    HRV is actually a good indicator of a dysfunction in the Autonomic Nervous System (ANS).  The Autonomic Nervous Sy...

Wnt, TCF4 and Pre-myelinating Oligodendrocytes

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Cartoons in art class - Monty is getting ready for Easter break, but not in the Maldives Today’s post may sound very complicated and narrow, but it is very relevant to people with the following: -   ·         Pitt Hopkins Syndrome (insufficient expression of the Transcription Factor #4   TCF4 gene) ·         Multiple Sclerosis ·         Some Mental Retardation/Intellectual Disability (MR/ID) ·         Schizophrenia ·         Impaired Wnt signalling ·         Perhaps PAK1 inhibitor responders I do feel that Multiple Sclerosis could be treated very much better if some effort was made to translate the existing science, freely available to all, into therapy. You could greatly improve many people’s lives just by repurposing cheap existing drugs. In simple terms, to produce m...