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Showing posts from November, 2019

PolyPill v6 for Severe Autism and now for Smartphones

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From my blog statistics I know that many people rely on their smartphone to figure out autism.  Most people look at diets and supplements; I can see that from what words people have put in their Google searches. This blog is about anything that actually works and very often that ends up being a pharmaceutical, which is the last thing most people want to hear. Today we have a video post on YouTube.  It is a power PowerPoint presentation with narration;  this seems to be the best way to view something on a smart phone. You can skip through it with volume off, or if you are interested in certain parts listen to the narration. It is not supposed to be a masterpiece, more of an experiment, without any script/rehearsal/editing. There is a preamble since not everyone is a regular reader of the blog. It is really just another way to spread the word that severe autism is treatable, even if that does open Pandora's box.  You can either click the image at the start of this post...

Ordinary Gifted or Gifted with Asperger’s Syndrome? And Treatment options for Aspies

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Asperger with his Little Professors This blog is focused more on severe autism, but today it is turn for the Aspies.   The post does rather ramble, because I included some old unused material on micro-dose LSD that may be Aspie-relevant. Most people diagnosed with autism these days do not have severe autism and so their ideal medical therapy may be very different to the Polypill, I developed for my son. For a young Aspie he might just need a single intervention like Sertraline (Zoloft) and nothing else, or perhaps Amantadine. There is more than twenty years of experience medically treating people with Asperger’s, but it very much remains a case of trial and error to find what works. It does look like most translational research in autism is now focused on those without problems with speech or cognition. That is good news for people with Asperger’s, not so good for the other end of the spectrum. The paper below is 20 years old, but the medical treatment has not become out of date. G...

Dentistry Gangnam-Style vs Native American (Papoose) - Style

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' There have been previous posts in this blog about dental treatment for those with autism.   I am sure readers with older children have already found what works for them.   Many people are not regular readers, so there is some repetition in today’s post. There is no single best solution for the dentist because your options are very different depending on where you live and your budget. In the US you have the widest choice, but they are all pricey. In other countries there are more legal restrictions. Some countries with universal healthcare have well organised free solutions for those with special needs, but you may have little choice. In many countries all the options are pretty bad. It looks like US dentists are taught two broad options: - ·         Sedation ·         Immobilization I think they are often missing a missing a third option, D-Termined or similar, which I think is the best one. Sedation Ther...

Metformin to raise Cognition in Fragile X and some other Autisms?

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I started to write this post a long time ago, when Agnieszka first highlighted an interview with Dr Hagerman from UC Davis.  Hagerman is experimenting in using Metformin to treat Fragile-X. Having again be reminded about Metformin, I realized that I never finished my post on this subject. With some extras about autophagy and a nice graphic courtesy of Ling’s excellent paper, here it is.   Metformin has already been covered in 5 previous posts. https://epiphanyasd.blogspot.com/search/label/metformin One interesting point is that the researchers at UC Davis are using the measurement of IQ as one of the outcome measures in their trial of Metformin.   I have been suggesting the French Bumetanide researchers do this for a long time. It is my opinion that simple medical interventions can have a profound impact on the IQ of some people with severe autism. I mean raising IQ not by 5-10 points as at UC Davis, but by 20-50 points.   IQ can be measured using standardized tools ...