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Showing posts from January, 2020

Piperine/Resveratrol/Sunitinib for Rett’s and indeed much Autism? Or, R-Baclofen to raise KCC2 expression in Bumetanide-responsive autism.

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Piperine/Pepper             Resveratrol/Red wine          Sunitinib/Sutent    This post is all about lowering chloride within neurons, by increasing the expression of the transporter that lets it leave, called KCC2. Today’s post is one I never finished writing from last year; I looked up the price of Sutent/Sunitinib and then I remembered why. It does again highlight how cancer drugs, when they become cheap generics, will provide interesting options for autism treatment. It also shows again how Rett Syndrome is getting attention from researchers. It also highlights that really clever Americans are looking for bumetanide alternatives, in the false belief that bumetanide has troubling side effects that cannot be managed/mitigated. The study is by some clever guys in Cambridge Massachusetts. Another group of clever guys from MIT burned through $40 million dollars a few years ago trying to develop R-Baclofen for Fragile-X...

Sulfarlem / Anethole trithione (AOL) for Autism secondary to Mitochondrial Dysfunction (AMD)? Not to mention Metastasis

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Sulfarlem has been used to treat dry mouths for half a century By www.scientificanimations.com - http://www.scientificanimations.com/wiki-images/, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=77499374 Sulfarlem is a drug containing a chemical called Anethole trithione . Anethole is an organic compound used as a flavouring, i t contributes a large component of the odour and flavour of anise and fennel. Anise seed, or aniseed, contains a large amount of Anethole. The popular Greek drink Ouzo turns cloudy when diluted with water because of the Anethole. For the French it is called Pastis.                                                                  ...