PLT Test Blog

  They also had Pentoxifylline for autism back in the 1970s – time for a revival?   Pentoxifylline and other more modern PDE inhibitors have been mentioned many times in this blog. https://epiphanyasd.blogspot.com/search/label/PDE4 https://epiphanyasd.blogspot.com/search/label/Pentoxifylline Pentoxifylline has been used in autism clinical trials dating back almost 50 years. A casual observer would naturally assume it cannot possibly be effective, or else surely its use would have caught on by now. Some readers have long been using a PDE inhibitor as part of their child’s autism polytherapy. People have been asking me to let them know my thoughts on Pentoxifylline, the most accessible PDE inhibitor. I think the key is that we are talking about an add-on, or adjunct, therapy.   We are no longer talking about pentoxifylline therapy vs no therapy, as they were in the 1970s.   Even in those decades-old studies there was a sub group of “super responders”.   Either...

  Monty has been skiing for many years, after a shaky start when he was 5 years old.   He went to a small ski school in Austria where they only teach kids with special needs. The Porsche family own the ski lifts in Zell am See and give the school free tickets, so at least you don’t have to pay for that part.   Skiing is never cheap, but our local slopes are less than four hours drive away and those one-to-one lessons are a fading memory. Big brother had gone for a week skiing with his friends and he stayed on so he could accompany Monty for 3 days of skiing. Even though Monty is actual a very safe skier, people tend not to believe it and they think he must have constant supervision.   In reality, he goes up the ski lift with his brother and he can make his way down entirely by himself.   His brother takes him to all the slopes but mainly the black ones (the hardest), far out of sight of their parents. This year Monty was on skis and his brother was learning s...

  62 clinical trials with Psilocybin are registered Today’s post is about treating a wide range of conditions that share neuroinflammation in common, by targeting the serotonin receptor 5-HT 2A . Severely disabling cluster headaches, that were seen as untreatable, have been resolved by monthly micro dosing with psilocybin. Psilocybin is a naturally occurring prodrug compound produced by more than 200 species of fungus, including magic mushrooms. Psilocybin is quickly converted by the body into Psilocin.   Psilocin Binding Profile Target Affinity Species   K i  (nM)   SERT 3,801.0 Human   5-HT 1A 567.4 Human   5-HT 1B 219.6 Human   5-HT 1D 36.4 Human   5-HT 1E 52.2 Human   5-HT 2A 107.2 Human   5...