PLT Test Blog

  Memantine, Arbaclofen  and now Bumetanide stumble in clinical trials (also the less well known Balovaptan, which Roche dropped in 2020). Place your bets on Suramin, anyone?   Plus ça change ,  plus  c'est la  même chose The more things change, the more they stay the same The first week of the school year brought two big surprises.  Monty, aged 18 with autism, came top of the class in the math test.  This is a big win for bumetanide treatment, because 9 years ago Monty was effectively innumerate.  With a huge effort by his Assistant, he had learnt how to read and write, but even the most basic maths was beyond him.  That all changed in 2012 thanks to Professor Ben-Ari’s published research on Bumetanide in autism. The sad news that week was that the Phase 3 clinical trial of Bumetanide for autism had been terminated early.    Servier and Neurochlore announce the main results of the two phase 3 clinical studies assessing...

    A pathway to somewhere, hopefully Today’s post was prompted by our reader George’s observation that the probiotic Lactobacillus Plantarum 299v increased speech in his adult son.   This widely available probiotic is commonly used to treat IBS (Irritable Bowel Syndrome) and I did mention it in a recent post about Eubiotics. Eubiotics for GI Dysfunction and some Autism Increased speech is a target for many people treating autism and this probiotic is known to be safely used long term - so it is interesting. Since I already had this probiotic at home, I made a trial and I observed a very similar effect to what happened several years ago when Monty started to use Sulforaphane / broccoli sprout powder.   The effect of broccoli powder was a brief period of euphoria about 20 minutes later and a then a marked increase in verbalization.   The effect on mood was seen by some other readers, but not the majority. I recall back then a very happy parent who was feedin...