PLT Test Blog

Most of what you can read on the internet regarding autism is parents writing about their young children, or alternatively middle-aged Aspies with their very diverging views (either self treating on Reddit/Longcity, or campaigning for no treatment at all, for anyone). I don’t delve into Facebook and its often closed groups, that some people now want banned. G oogle has closed Google+, which did carry this blog.  Since teenagers and adults also have autism, you might expect them also to be a common topic. They are not. Did all the young kids with autism “get better”? Sadly, not the case. Did the parents just run out of energy?   Most likely the case. Autism blogs do seem to just stop abruptly, rather than fade away gradually. Hope springs eternal The reason put forward for the mass use of ABA, but almost exclusively only in North America, is that parents really want to do “something”. ABA is "evidence-based", expensive, time-consuming and often you have to fight for it, so it...

I did think we had finished with Clemastine for a while, but a researcher reader of this blog sent me a very interesting recent case study about a man with brain damage caused by hypoxia (lack of oxygen) and we have the MRI brain scans showing how that damage was reversed by this OTC antihistamine. Hypoxia is often caused by carbon monoxide poisoning or in childbirth, if things get tangled up. The researchers go on to suggest Clemastine treatment to promote myelin recovery in premature infants. In this case the graphics in the paper relate to mice, not humans, but are really impressive. This means that what is called Ataxic Cerebral Palsy, which is caused by a lack of oxygen during birth might now have a treatment. Some children with autism, including some discussed in the comments in this blog, appear to have suffered hypoxia during birth. This caused damage which resulted in symptoms of autism.   You would expect that damage to show up on the “right sort of MRI” in the same wa...

Today’s post is mainly about some “home-research” that was sent to me by a company that sold me C8 oil (caprylic acid MCT oil). It is not peer-reviewed research, but it is a well thought out home experiment measuring the level of the ketone BHB in the blood of two healthy young adults testing a range of commercially available products. It is important to note that BHB was measured in blood and not urine, which is a big plus for the experiment. Dr D’Agostino’s starting dose First, a recap of where we started a few months ago in this blog. One of the leading ketone researchers is Dr D’Agostino and his suggested starting dose on ketone supplements is 10 ml of Ketoforce and 10ml of C8/caprylic acid. We saw in earlier posts that the amount of BHB produced by taking C8 is highly dependent on whether it is taken with food. Taken on an empty stomach resulted in more BHB in the bloodstream. 10 ml of KetoForce contains 4g of BHB along with 500mg of sodium and 500mg of potassium. BHB salts and BH...

Nibbling on Neurons – This is synaptic pruning Microglia (red) "nibble" a bit of filopodia (green), the membranous protrusions found primarily on dendritic stretches of developing neurons. Video from Weinhard, et al., Nature Communications, " Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction ," Today it is the post anticipated by Valentia in Uruguay, where it is currently hot and sunny. For Roger it is still winter and he may not be a fan today’s deep dive into the science, but I think he has already got the message about Clemastine’s potential for myelination, including, and importantly for him, in the peripheral nervous system (i.e. for myelination outside the brain).  If my posts get too complicated just skip down to the conclusion. I do go a little off-topic looking at EPA and DHA. We also take a deep look at microglia in psychiatric disorders. Today we see how Clemastine’s benefit in some people may be related to its effe...