Bumetanide Dosage & Effectiveness in Autism & Asperger's



The clinical trial of Bumetanide in autism, published in 2012, was what triggered my interest in using drugs to treat autism.


In that trial on children aged 3-11 years, the dosage used was 1mg a day, split in two doses.

In my trial, I found 1mg in the morning effective, while splitting the dose rendered it ineffective. 
I was surprised to hear that the French researchers find the treatment effective in 90% of cases of autism, including Asperger’s.  The reason is that while Monty, now aged 10 with ASD, is a responder, it seems that most people I know who have tried it have not responded.  Only one did respond, and that was when the father upped the dosage.

Now I hear that Lemmonier’s standard dosage has doubled to 2mg a day, with 1mg in the morning and 1mg at 5pm.  He tries for three months, before assuming the drug to be ineffective.
So to anyone who tried Bumetanide without success, maybe it is time to try again at the revised dosage and see if you are in the 90%.

The researchers are also suggesting Bumetanide is given from a very early age, as soon as autism is suspected.


 

Comments

  1. AnonymousFebruary 20, 2014 at 6:46 AM

    Hi Peter! I am reading with great interest about you quest to create a pill. We are happy to trial it when you are ready. In the meantime I am still struggling to get hold of Bumetanide as even on line you need a prescription. Any advice? Many thanks Monica

    ReplyDelete
  2. Peter Lloyd-ThomasFebruary 20, 2014 at 7:15 AM

    I am not an expert on internet pharmacies, but there are plenty of them (in Mexico and the South Pacific) who are sending precription only medicines like T3, thyroid hormones, without a precription to older people in the UK. If you look on the forums they use to discuss their health you will find them. Some internet pharmacies are scams, but not all. Some of them charge you extra for them to provide a "prescription" that they mail with the drug. A long time ago I did look into it and you could buy bumetanide in this way, it just takes a while to find it. In Spanish it is called Miccil, other name is Bumex.

    I just looked and found this one:-

    http://www.mexmeds4you.com/productdetails.asp?pid=2220

    Use Paypal, just to be on the safe side. I have no idea if they are genuine.

    The older ladies in the UK buying T3 from Mexico will be able to recommend a reliable supplier.

    ReplyDelete
  3. AnonymousFebruary 21, 2014 at 1:49 AM

    Hope readers of this blog who used Bumetanide can write feed-ups, so we can share experiences. In 2013 I tried with 0.5 mg +1 mg / day for 6 weeks, no effect seen. And now I tried 1 mg +1 mg / day for 1 weeks, no effect seen, I feel it is better for me to stop for now. Peter, you may give link to the recent Science paper. Yi

    ReplyDelete

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