Histamine Reaction to Bio Gaia Gastrus



Alli from Switzerland discovered the autism benefits of Bio Gaia Gastrus.

This probiotic contains two different bacteria:-

·        Lactobacillus reuteri 17938 (Lactobacillus reuteri Protectis)

 ·        Lactobacillus reuteri ATCC PTA 6475


These two bacteria have different effects.

The first bacteria is very well researched and recently was shown to increase oxytocin in autism mouse studies.  It is available on its own and this is the product most people I know are using.

The second bacteria is included in Bio Gaia Gastrus specifically for its additional anti-inflammatory effects.

Recent comments on this blog have shown that some people have a negative “histamine-y" reaction to Bio Gaia Gastrus.  This is entirely logical since the mode of action of the second bacteria is to generate histamine to activate H2 receptors in the gut.

This might sound rather odd since histamine is thought of as inflammatory, but the researchers working for Bio Gaia have shown that histamine can produce the opposite effect, suppressing TNFvia Modulation of PKA and ERK Signaling.


Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling


Beneficial microbes and probiotic species, such as Lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity. Previously, immunomodulatory factors secreted by L. reuteri ATCC PTA 6475 were unknown. A combined metabolomics and bacterial genetics strategy was utilized to identify small compound(s) produced by L. reuteri that were TNF-inhibitory. Hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC) separation isolated TNF-inhibitory compounds, and HILIC-HPLC fraction composition was determined by NMR and mass spectrometry analyses. Histamine was identified and quantified in TNF-inhibitory HILIC-HPLC fractions. Histamine is produced from L-histidine via histidine decarboxylase by some fermentative bacteria including lactobacilli. Targeted mutagenesis of each gene present in the histidine decarboxylase gene cluster in L. reuteri 6475 demonstrated the involvement of histidine decarboxylase pyruvoyl type A (hdcA), histidine/histamine antiporter (hdcP), and hdcB in production of the TNF-inhibitory factor. The mechanism of TNF inhibition by L. reuteri-derived histamine was investigated using Toll-like receptor 2 (TLR2)-activated human monocytoid cells. Bacterial histamine suppressed TNF production via activation of the H2receptor. Histamine from L. reuteri 6475 stimulated increased levels of cAMP, which inhibited downstream MEK/ERK MAPK signaling via protein kinase A (PKA) and resulted in suppression of TNF production by transcriptional regulation. In summary, a component of the gut microbiome, L. reuteri, is able to convert a dietary component, L-histidine, into an immunoregulatory signal, histamine, which suppresses pro-inflammatory TNF production. The identification of bacterial bioactive metabolites and their corresponding mechanisms of action with respect to immunomodulation may lead to improved anti-inflammatory strategies for chronic immune-mediated diseases.


This may mean that people who respond well to H2 histamine antagonists (Zantac, Tagamet etc) are unlikely to benefit from Lactobacillus. reuteri ATCC PTA 6475.

It might also mean that people who respond negatively to Bio Gaia Gastrus might get benefit from H2 histamine antagonists.

It might be worthwhile people trialing the single bacteria Bio Gaia product (Protectis), if they have a negative reaction to Gastrus.






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