PLT Test Blog

Click this link  http://sfari.org/sfari-community/community-blog/webinar-series/2015/webinar-william-catterall-examines-anxiety-drugs-for-autism/ This post will be mainly of interest to the small number of people using low-dose clonazepam for autism and those considering doing so. This therapy modifies the excitatory/inhibitory (im)balance between the GABA and Glutamate neurotransmitters.  The big advantage is that it should be very safe, is extremely inexpensive and, unlike Bumetanide, does not cause diuresis.   The disadvantage is that the effective dose is only in a narrow window, and you have to find it by trial and error. Does it work? It certainly does work in some children with autism. It also appears to have an additional effect over Bumetanide alone, at least my son. Questions remain: ·         Does it work with everyone who responds to bumetanide? ·         Does it only work in people wit...

Kagome is a very large Japanese food company that you have never heard of, with an R&D team capable of producing standardized stable Sulforaphane- glucosinolat e.    I recently received some papers about Sulforaphane from a reader of this blog and also comments from people with schizophrenia looking for therapies Sulforaphane is already a valued part of my autism Polypill for Monty, aged 12 with ASD.  Just google "Sulforaphane Epiphany", or use the site index tab on this blog. Sulforaphane has been patented for various purposes by John Hopkins, however even after twenty years they have not brought to market a standardized product.  The Sulforaphane (SFN) used in their research is made in the lab and then has to be kept deep frozen. Sulforaphane is not a stable substance and so you are wasting your money buying most supplements.  Even most types of broccoli powder, which should be a precursor to Sulforaphane (SFN), were shown to be ineffective in inde...

I have written several posts about Cinnamon and its metabolite Sodium Benzoate. I know that some readers are now using it for its cholesterol lowering and insulin sensitivity improving properties that were shown in the clinical trials I highlighted. Cinnamon and DJ-1 as a general Anti-Oxidant and perhaps Much More Is DJ-1 expression negatively associated with severity of Autism? If so, Sodium Benzoate (Cinnamon) may well be beneficial Sodium benzoate (Cinnamon) trialed for Schizophrenia (Adult-onset Autism) NMDAR hypo-function causing E/I imbalance in Autism and Schizophrenia – Baclofen, Sodium benzoate and Cinnamon (again) But has anyone tried it for autism? The first time I wrote about it I did acquire a big bag of the correct variety ( Cinnamomum verum or Ceylon Cinnamon) and also a bag of the very high flavanol ( epicatechin ) cocoa.  My cinnamon trial was limited to seeing what it looked/tasted like when added to the Polypill concoction Monty, aged 12 with ASD, drinks at brea...

Click on figure to enlarge Source of text quoted:    E-I Balance and Human Diseases – from Molecules to Networking Interpretation, extrapolation and graphic - Peter   Today’s post is not the one I intended. It nearly got tucked into long complicated one, that most people might not read. I should caution that I am perhaps over-simplifying something that is extremely complicated, but no one fully understands the subject. There is much talk in autism about the imbalance between excitatory and inhibitory processes. In this blog this is normally all about the inhibitory neurotransmitter, GABA, not functioning properly. There is of course another side to the story.  The excitatory neurotransmitter Glutamate signals via receptors including the NMDA receptors.  If signaling via these receptors is either up or downregulated, the delicate balance between excitatory and inhibitory can again be lost. What caught my interest was an experiment on mice that caused downregula...